N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Base Information

• Chemical Name: N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
• CAS No.: 1040379-55-2
• Molecular Formula: C₁₈H₂₄AsN₃O₂S₃
• Molecular Weight: 485.527
• Mol file: 1040379-55-2.mol

Synonyms:N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Chemical Property of N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

There total 4 articles about N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

[4-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)phenyl]arsonous acid + ethane-1,2-dithiol (540-63-6) → N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (1040379-55-2)

Guidance literature:

In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2008.03.054

Reference yield: 72.0%

4-(1,3,2-dithiocycloarsenic-2-yl)aniline (5577-20-8) + biotin (58-85-5,22879-79-4) → N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (1040379-55-2)

Guidance literature:

biotin; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

4-(1,3,2-dithiocycloarsenic-2-yl)aniline; With dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 - 60 ℃; for 28h;

DOI:10.1002/chem.201300567

Reference yield:

p-aminophenylarsonic acid (98-50-0) → N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (1040379-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phenylhydrazine / methanol / 1.17 h / Reflux

2.1: ethanol / 0.17 h / Reflux

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 3 h / 20 °C

3.2: 28 h / 20 - 60 °C

With benzotriazol-1-ol; phenylhydrazine; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201300567

upstream raw materials:

ethane-1,2-dithiol

p-aminophenylarsonic acid

4-(1,3,2-dithiocycloarsenic-2-yl)aniline

biotin