(+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester

Base Information

• Chemical Name: (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester
• CAS No.: 916046-27-0
• Molecular Formula: C₁₇H₁₉NO₄
• Molecular Weight: 301.342
• Mol file: 916046-27-0.mol

Synonyms:(+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester

Chemical Property of (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester

There total 4 articles about (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-methoxy-phenyl)-(4-methoxy-phenylimino)-acetic acid methyl ester → (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester (916046-27-0)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₅H₃₅FeI₂NO₂P₂; hydrogen; iodine; In tetrahydrofuran; at 0 ℃; for 24h; under 37503.8 Torr; enantioselective reaction; Autoclave;

DOI:10.1002/adsc.201900888

Reference yield:

methyl 2-diazo-2-(4-methoxypheny)acetate (22979-36-8) + 4-methoxy-aniline (104-94-9) → (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester (916046-27-0) + methyl (R)-2-(4-methoxyphenyl)-2-((4-methoxyphenyl)amino)acetate

Guidance literature:

With C₃₇H₂₇O₄P; In dichloromethane; at 45 ℃; for 16h; Overall yield = 94 percent; enantioselective reaction;

DOI:10.1002/anie.202102506

Reference yield:

methyl 2-(4-methoxyphenyl)-2-((4-methoxyphenyl)amino)acetate (121766-30-1) → (+)-(4-methoxyphenyl)-(4-methoxyphenylamino)acetic acid methyl ester (916046-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper dichloride; oxygen / 1,2-dichloro-ethane / 50 °C / 760.05 Torr

2: (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate; 2-Phenylbenzothiazolin / 1,3,5-trimethyl-benzene / 6 h / 50 °C / Inert atmosphere

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate; 2-Phenylbenzothiazolin; oxygen; copper dichloride; In 1,2-dichloro-ethane; 1,3,5-trimethyl-benzene;

DOI:10.1016/j.tetlet.2020.152107

upstream raw materials:

4-methoxyphenylglyoxylate methyl ester

4-methoxy-aniline

methyl 2-(4-methoxyphenyl)-2-((4-methoxyphenyl)amino)acetate

methyl 2-diazo-2-(4-methoxypheny)acetate