3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Base Information

Chemical Name:3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester
CAS No.:626249-50-1
Molecular Formula:C₂₅H₃₈O₃Si
Molecular Weight:414.66
Hs Code.:

Synonyms:3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Suppliers and Price of 3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

There total 5 articles about 3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 626249-49-8
1-(tert-butyldimethylsilanyloxy)-9-phenylnon-8-yn-4-one

: 626249-50-1
3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at -78 - 20 ℃;

1-(tert-butyldimethylsilanyloxy)-9-phenylnon-8-yn-4-one; In tetrahydrofuran; at -78 - 65 ℃;
DOI:10.1021/ja037423w

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 626249-50-1
3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / CuI; iPr₂NH; Pd(Ph₃)4 / tetrahydrofuran / 20 °C

2.1: 95 percent / PCC / CH₂Cl₂ / 5 h / 35 °C

3.1: 98 percent / hexane; diethyl ether / 2 h / -40 - 20 °C

4.1: 77 percent / dimethylsulfoxide; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C

5.1: NaH / tetrahydrofuran / -78 - 20 °C

5.2: 82 percent / tetrahydrofuran / -78 - 65 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 4.1: Swern oxidation;
DOI:10.1021/ja037423w

Reference yield:

: 130602-09-4
6-phenylhex-5-yn-1-al

: 626249-50-1
3-[3-(tert-butyldimethylsilanyloxy)propyl]-8-phenyloct-2-en-7-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / hexane; diethyl ether / 2 h / -40 - 20 °C

2.1: 77 percent / dimethylsulfoxide; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: NaH / tetrahydrofuran / -78 - 20 °C

3.2: 82 percent / tetrahydrofuran / -78 - 65 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ja037423w