6-Phenylnicotinoyl chloride

Base Information

• Chemical Name: 6-Phenylnicotinoyl chloride
• CAS No.: 257876-10-1
• Molecular Formula: C12H8 Cl N O
• Molecular Weight: 217.655
• Mol file: 257876-10-1.mol

Synonyms:6-PHENYLNICOTINOYL CHLORIDE

Chemical Property of 6-Phenylnicotinoyl chloride

Chemical Property:

• Melting Point: 107 °C
• PSA: 29.96000
• LogP: 3.12760

Purity/Quality:

98%min ^*data from raw suppliers

6-PHENYLNICOTINOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Phenylnicotinoyl chloride

There total 3 articles about 6-Phenylnicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-phenylpyridine-3-carboxylic acid (29051-44-3) → 6-phenylnicotinoyl chloride (257876-10-1)

Guidance literature:

With thionyl chloride; at 60 ℃; for 1h;

DOI:10.1016/j.tetasy.2012.10.005

Reference yield:

phenylboronic acid (98-80-6) → 6-phenylnicotinoyl chloride (257876-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 110 °C

2: oxalyl dichloride / dichloromethane / 4 h / 0 - 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; sodium carbonate; In 1,4-dioxane; dichloromethane;

Reference yield:

→ 6-phenylnicotinoyl chloride (257876-10-1)

Guidance literature:

entspr. Saeure, SOCl2;

upstream raw materials:

6-phenylpyridine-3-carboxylic acid

phenylboronic acid

Downstream raw materials:

methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate

methyl 3-{[hydrazino(6-phenylpyridin-3-yl)methylene]amino}-2-methylbenzoate

methyl 3-[3-ethyl-5-(6-phenylpyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2-methylbenzoate

3-[3-ethyl-5-(6-phenylpyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2-methylbenzoic acid

Refernces

• 1、 -. "P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS". Paragraph 0307-0308. . Retrieved 2018/04/17.