methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate

Base Information

• Chemical Name: methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate
• CAS No.: 1416057-62-9
• Molecular Formula: C₂₁H₁₈N₂O₃
• Molecular Weight: 346.386
• Mol file: 1416057-62-9.mol

Synonyms:methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate

Chemical Property of methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate

There total 2 articles about methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-amino-2-methylbenzoate (18583-89-6) + 6-phenylnicotinoyl chloride (257876-10-1) → methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate (1416057-62-9)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tetasy.2012.10.005

Reference yield:

6-phenylpyridine-3-carboxylic acid (29051-44-3) → methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate (1416057-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 60 °C

2: pyridine / tetrahydrofuran / 1 h / 0 - 20 °C

With pyridine; thionyl chloride; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2012.10.005

Reference yield: 100.0%

methyl 2-methyl-3-{[(6-phenylpyridin-3-yl)carbonyl]amino}benzoate (1416057-62-9) → C21H19ClN2O2

Guidance literature:

With thionyl chloride; at 80 ℃; for 1h;

DOI:10.1016/j.tetasy.2012.10.005

upstream raw materials:

methyl 3-amino-2-methylbenzoate

6-phenylnicotinoyl chloride

6-phenylpyridine-3-carboxylic acid

Downstream raw materials:

methyl 3-{[hydrazino(6-phenylpyridin-3-yl)methylene]amino}-2-methylbenzoate

methyl 3-[3-ethyl-5-(6-phenylpyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2-methylbenzoate

3-[3-ethyl-5-(6-phenylpyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2-methylbenzoic acid