1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

Base Information

Chemical Name:1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione
CAS No.:103373-59-7
Molecular Formula:C₁₅H₁₂FN₃S
Molecular Weight:285.345
Hs Code.:

Synonyms:1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

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Chemical Property of 1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

Chemical Property:

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Technology Process of 1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

There total 2 articles about 1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103373-53-1
<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

: 103373-59-7
1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

Guidance literature:: With hydrogen bromide; In dichloromethane; acetic acid; for 6h;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-52-0
(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

: 103373-59-7
1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: HBr gas / CH₂Cl₂; acetic acid / 6 h

With Lawessons reagent; hydrogen bromide; In dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-59-7
1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

: 74-11-3
para-chlorobenzoic acid

: 103373-58-6
1,3-Dihydro-5-(2-fluorophenyl)-3-(4-chlorophenyl)-carbonylamino-2H-1,4-benzodiazepin-2-thione

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 18h;
DOI:10.1021/jm00396a028