Diethyl butyrylmalonate

Base Information

• Chemical Name: Diethyl butyrylmalonate
• CAS No.: 3378-01-6
• Molecular Formula: C11H18 O5
• Molecular Weight: 230.261
• Hs Code.: 2918300090
• Mol file: 3378-01-6.mol

Synonyms:Malonicacid, acetylethyl-, diethyl ester (7CI,8CI); Propanedioic acid, acetylethyl-,diethyl ester (9CI); Diethyl 2-acetyl-2-ethyl malonate

Chemical Property of Diethyl butyrylmalonate

Chemical Property:

• Boiling Point: 131oC/1.7kPa。 用途 丁酰基丙二酸二乙酯(3378-01-6)的用途：
• PSA: 69.67000
• LogP: 1.09800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl butyrylmalonate

There total 9 articles about Diethyl butyrylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(2-Benzenesulfonyl-acetyl)-2-ethyl-malonic acid diethyl ester (93845-22-8) → diethyl (acetyl)ethylmalonate (3378-01-6)

Guidance literature:

With aluminium amalgam; In tetrahydrofuran; water; at 80 ℃; for 2h;

DOI:10.1246/cl.1984.1517

Reference yield: 24.0%

2-Ethyl-2-(2-phenylsulfanyl-acetyl)-malonic acid diethyl ester (93845-20-6) → diethyl (acetyl)ethylmalonate (3378-01-6) + ethyl diethyl malonate (133-13-1)

Guidance literature:

With nickel; In acetone;

DOI:10.1246/cl.1984.1517

Reference yield:

2-Ethyl-2-((Z)-1-methoxy-2-phenylsulfanyl-vinyl)-malonic acid diethyl ester (93845-18-2,93845-19-3) → diethyl (acetyl)ethylmalonate (3378-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Me₃SiI, 2) MeOH / 1)CDCl₃, 6 d

2: 20 percent / Raney Ni / acetone

With methanol; trimethylsilyl iodide; nickel; In acetone;

DOI:10.1246/cl.1984.1517

upstream raw materials:

2-Ethyl-2-(2-phenylsulfanyl-acetyl)-malonic acid diethyl ester

2-(2-Benzenesulfonyl-acetyl)-2-ethyl-malonic acid diethyl ester

acetyl chloride

diethyl ether

Downstream raw materials:

ethylmalonic acid

acetic acid

ethyl diethyl malonate

ethyl acetate

Refernces