2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

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Chemical Name:2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile
CAS No.:948017-39-8
Molecular Formula:C₂₅H₁₈FN₉OS₂
Molecular Weight:543.608
Hs Code.:

Synonyms:2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

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Chemical Property of 2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

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Technology Process of 2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

There total 2 articles about 2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 948017-38-7
2-amino-4-[4-(2-azidoethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

: 459-05-2
(4-fluoro-phenyl)-thiourea

: 534-07-6
1,3-Dichloroacetone

: 948017-39-8
2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

Guidance literature:: (4-fluoro-phenyl)-thiourea; 1,3-Dichloroacetone; In ethanol; at 85 ℃; for 1h;

2-amino-4-[4-(2-azidoethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield: 47.0%

: 948017-38-7
2-amino-4-[4-(2-azidoethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

: 534-07-6
1,3-Dichloroacetone

: 948017-39-8
2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

Guidance literature:: (4-fluoro-phenyl)-thiourea; 1,3-Dichloroacetone; In ethanol; at 85 ℃; for 1h;

2-amino-4-[4-(2-azidoethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield: 6.0%

: 948017-39-8
2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile

: 2-amino-4-[4-(2-aminoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile hydrochloride

Guidance literature:: 2-amino-4-[4-(2-azidoethoxy)phenyl]-6-[({2-[(4-fluorophenyl)amino]-1,3-thiazol-4-yl}methyl)-thio]pyridine-3,5-dicarbonitrile; With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; water; for 23h; under 2250.23 Torr;

With sodium hydrogencarbonate; In water; acetic acid; pH=9;

With hydrogenchloride; In water; acetonitrile;