Technology Process of (S,Z)-methyl 2-(benzyloxy)dec-4-enoate
There total 4 articles about (S,Z)-methyl 2-(benzyloxy)dec-4-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S,Z)-2-(benzyloxy)-1-(1-methyl-1H-imidazol-2-yl)dec-4-en-1-one;
With
methyl trifluoromethanesulfonate;
In
dichloromethane;
at 20 ℃;
for 20h;
Inert atmosphere;
Molecular sieve;
methanol;
With
sodium methylate;
In
dichloromethane;
at 20 ℃;
for 3.5h;
Inert atmosphere;
Molecular sieve;
DOI:10.1016/j.tetlet.2012.06.052
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: phosphorus tribromide / diethyl ether; dichloromethane / 3 h / 0 °C / Inert atmosphere
2.1: cesiumhydroxide monohydrate; Br(1-)*C29H32F3N2O(1+) / hexane; dichloromethane / 23 h / -60 °C / Inert atmosphere
3.1: methyl trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere; Molecular sieve
3.2: 3.5 h / 20 °C / Inert atmosphere; Molecular sieve
With
cesiumhydroxide monohydrate; Br(1-)*C29H32F3N2O(1+); phosphorus tribromide; methyl trifluoromethanesulfonate;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tetlet.2012.06.052
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: cesiumhydroxide monohydrate; Br(1-)*C29H32F3N2O(1+) / hexane; dichloromethane / 23 h / -60 °C / Inert atmosphere
2.1: methyl trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere; Molecular sieve
2.2: 3.5 h / 20 °C / Inert atmosphere; Molecular sieve
With
cesiumhydroxide monohydrate; Br(1-)*C29H32F3N2O(1+); methyl trifluoromethanesulfonate;
In
hexane; dichloromethane;
DOI:10.1016/j.tetlet.2012.06.052
