(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

Base Information

Chemical Name:(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid
CAS No.:1615230-71-1
Molecular Formula:C₁₅H₁₆N₃O₃PS
Molecular Weight:349.35
Hs Code.:

Synonyms:(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

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Chemical Property of (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

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Technology Process of (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

There total 5 articles about (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2041-14-7
(2-aminethyl)phosphonic acid

: 1610772-26-3
4-chloro-6-(p-tolyl)thieno[2,3-d]pyrimidine

: 1615230-71-1
(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

Guidance literature:: With triethylamine; In 1,4-dioxane; at 100 ℃; Sealed tube;
DOI:10.1021/jm500629e

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1615230-71-1
(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

2: triethylamine / 1,4-dioxane / 100 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In 1,4-dioxane; water; 1: |Suzuki Coupling;
DOI:10.1021/jm500629e

Reference yield:

: 14080-50-3
thieno[2,3-d]pyrimidin-4(3H)one

: 1615230-71-1
(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 80 °C

2: trichlorophosphate / 95 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

4: triethylamine / 1,4-dioxane / 100 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; water; 3: |Suzuki Coupling;
DOI:10.1021/jm500629e