2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

Base Information

Chemical Name:2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide
CAS No.:882036-91-1
Molecular Formula:C₁₈H₈BrF₅N₄O
Molecular Weight:471.184
Hs Code.:

2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2<i>H</i>-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

Synonyms:2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

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Chemical Property of 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

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Technology Process of 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

There total 2 articles about 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 882036-91-1
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 20 °C

2: Et₃N / CH₂Cl₂

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.01.010

Reference yield:

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 367-24-8
4-bromo-2-fluoroaniline

: 882036-91-1
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.01.010

Reference yield: 90.0%

: 882036-91-1
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-2-fluoro-phenyl)-amide

: 40138-16-7
2-formylbenzene boronic acid

: 882036-92-2
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-formyl-biphenyl-4-yl)-amide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; for 4h; Heating;
DOI:10.1016/j.bmcl.2006.01.010