benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

Base Information

Chemical Name:benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide
CAS No.:142966-69-6
Molecular Formula:C₃₀H₂₉N₃O₇S₂
Molecular Weight:607.708
Hs Code.:

Synonyms:benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

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Technology Process of benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

There total 1 articles about benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29126-13-4
3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

: 124-40-3
dimethyl amine

: 530-62-1
1,1'-carbonyldiimidazole

: 142966-69-6
benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

Guidance literature:: Yield given. Multistep reaction;
DOI:10.7164/antibiotics.47.1507

Reference yield: 79.0%

: 142966-69-6
benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

: 142966-70-9
benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate

Guidance literature:: With phosphorus trichloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.7164/antibiotics.47.1507

Reference yield:

: 142966-69-6
benzhydryl 7-(2-thienylacetamido)-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate-1-oxide

: benzhydryl 7-amino-3-N,N-dimethylcarbamoyloxymethyl-3-cephem-4-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / PCl₃ / dimethylformamide / 0.5 h / 0 °C

2: 74 percent / PCl₅, pyridine / CH₂Cl₂ / 1 h / -10 °C

With pyridine; phosphorus pentachloride; phosphorus trichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.47.1507