5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

Base Information

• Chemical Name: 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine
• CAS No.: 1421372-22-6
• Molecular Formula: C₂₄H₂₂ClN₇O₃
• Molecular Weight: 491.937
• Mol file: 1421372-22-6.mol

Synonyms:5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

Chemical Property of 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

There total 5 articles about 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (1224709-13-0) + 2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline (1421371-96-1) → 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine (1421372-22-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield:

4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2) → 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine (1421372-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / Inert atmosphere; Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

4-[(E)-2-butoxyethenyl]-2,5-dichloropyrimidine (1224708-12-6) → 5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine (1421372-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; potassium carbonate / dimethyl sulfoxide / 5.5 h / 20 - 90 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice

With potassium carbonate; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine

2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroaniline

4-bromo-2-methoxy-5-nitrobenzenamine

4-[(E)-2-butoxyethenyl]-2,5-dichloropyrimidine

Downstream raw materials:

N-(5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)-6-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)benzene-1,3-diamine

C₂₇H₂₆ClN₇O₂