(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

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Chemical Name:(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid
CAS No.:919988-49-1
Molecular Formula:C₅₃H₆₀N₄O₁₂
Molecular Weight:945.079
Hs Code.:

(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

Synonyms:(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

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Chemical Property of (2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

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Technology Process of (2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

There total 7 articles about (2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl 4-(4'-(benzyloxy)-3'-{(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)-3-({(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)butanoate

: 919988-49-1
(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

Guidance literature:: methyl 4-(4'-(benzyloxy)-3'-{(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)-3-({(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)butanoate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 919988-45-7
methyl 4-(3-bromophenyl)-3-[(tert-butoxycarbonyl)amino]butanoate

: 919988-49-1
(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 6 h / 50 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 0 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 919988-42-4
3-amino-4-(3-bromophenyl)butanoic acid

: 919988-49-1
(2S)-3-[4-(benzyloxy)-3'-(2-{[(2S)-5-{[(benzyloxy)carbonyl]amino}-2-(tert-butoxycarbonylamino)pentanoyl]amino}-4-methoxy-4-oxobutyl)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / methanol; water / 2 h / 20 °C

1.2: pH 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 0 - 20 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 6 h / 50 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 0 °C

With hydrogenchloride; sodium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;