Technology Process of benzo[b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(2-methoxy-benzylamide)
There total 2 articles about benzo[b]thiophene-2,5-dicarboxylic acid 2-hydroxyamide 5-(2-methoxy-benzylamide) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-trityloxycarbamoyl-benzo[b]thiophene-5-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 0.666667h;
2-methoxybenzylamine;
In
dichloromethane;
at 20 ℃;
With
triethylsilane; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium periodate / tetrahydrofuran; water / 3 h / 20 °C
2.1: sodium sulfide; acetic acid / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2.2: 22 h / 55 °C
3.1: trifluoroacetic acid / dichloromethane / 96 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 168 h / 20 °C
5.1: sodium hydroxide / tetrahydrofuran; water / 144 h / 20 °C
5.2: pH 4
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.67 h / 20 °C
6.2: 20 °C
6.3: 0.33 h / 20 °C
With
sodium sulfide; sodium hydroxide; sodium periodate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
