143484-14-4Relevant articles and documents
Synthesis and biological activities of novel indole derivatives as potent and selective PPARγ modulators
Lamotte, Yann,Martres, Paul,Faucher, Nicolas,Laroze, Alain,Grillot, Didier,Ancellin, Nicolas,Saintillan, Yannick,Beneton, Véronique,Gampe Jr., Robert T.
scheme or table, p. 1399 - 1404 (2010/07/06)
Starting from the structure of Telmisartan, a new series of potent and selective PPARγ modulators was identified. The synthesis, in vitro and in vivo evaluation of the most potent compounds are reported and the X-ray structure of compound 7b bound to the PPARγ ligand binding domain is described.
THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES
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Page/Page column 86, (2008/06/13)
The present invention relates to a novel class of hydroxamic acid derivatives having a benzothiophene or thiophene backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit historic deacetylase and