N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

Base Information

Chemical Name:N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate
CAS No.:288140-84-1
Molecular Formula:C₄₀H₃₇ClN₇O₁₂P
Molecular Weight:874.2
Hs Code.:

Synonyms:N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

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Chemical Property of N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

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Technology Process of N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

There total 5 articles about N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzoic acid 2-[{4-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-(2-chloro-phenoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 288140-84-1
N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

Guidance literature:: With dichloro-acetic acid; In dichloromethane; at 0 ℃; for 0.05h;
DOI:10.1021/ja992528d

Reference yield:

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 288140-84-1
N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: 2,4,6-triisopropylbenzenesulfonyltetrazolide; pyridine / 1 h / 20 °C

3: dichloroacetic acid / CH₂Cl₂ / 0.05 h / 0 °C

With pyridine; dichloro-acetic acid; 2,4,6-triisopropylbenzenesulfonyl tetrazolide; In tetrahydrofuran; dichloromethane; 1: Phosphorylation / 2: Phosphorylation / 3: Detritylation;
DOI:10.1021/ja992528d

Reference yield:

: 17331-53-2
3'-O-benzoylthymidine

: 288140-84-1
N-benzoyl-1'-deoxy-2'-isoadenosine-3'-[(2-chlorophenyl)(3'-O-benzoylthymidine-5'-yl)] phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-triisopropylbenzenesulfonyltetrazolide; pyridine / 1 h / 20 °C

2: dichloroacetic acid / CH₂Cl₂ / 0.05 h / 0 °C

With pyridine; dichloro-acetic acid; 2,4,6-triisopropylbenzenesulfonyl tetrazolide; In dichloromethane; 1: Phosphorylation / 2: Detritylation;
DOI:10.1021/ja992528d