N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1380309-69-2
Molecular Formula:C₃₀H₃₅NO₆
Molecular Weight:505.611
Hs Code.:

Synonyms:N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

: 75-36-5
acetyl chloride

: 1380309-69-2
N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 20947-59-5
N-(4-benzyloxy-3-methoxyphenethyl)-3-(3',4',5'-trimethoxyphenyl)propionamide

: 1380309-69-2
N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 25173-72-2
3-(3,4,5-trimethoxyphenyl)propanoic acid

: 1380309-69-2
N-acetyl-7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.007