(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

Base Information

Chemical Name:(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide
CAS No.:128901-35-9
Molecular Formula:C₃₆H₅₄N₆O₃
Molecular Weight:618.863
Hs Code.:

(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

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Chemical Property of (2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

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Technology Process of (2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

There total 5 articles about (2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503-74-2
3-methylbutyric acid

: 128901-35-9,130321-32-3
(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

3: 98 percent / ammonium formate / 10percent Pd/C / H₂O; ethanol / 2 °C

4: 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium formate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 128901-35-9,130321-32-3
(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

3: 98 percent / ammonium formate / 10percent Pd/C / H₂O; ethanol / 2 °C

4: 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium formate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 105852-42-4,105864-88-8,130227-93-9
(2RS)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-3-methylbutanoic acid

: 128901-35-9,130321-32-3
(2S,4S)-6-Cyclohexyl-4-hydroxy-5-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-acetylamino]-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

2: 98 percent / ammonium formate / 10percent Pd/C / H₂O; ethanol / 2 °C

3: 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

With ammonium formate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006