(1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

Base Information

• Chemical Name: (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol
• CAS No.: 915725-65-4
• Molecular Formula: C₂₆H₃₅NO₂
• Molecular Weight: 393.569

Synonyms:(1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

Chemical Property of (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

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Technology Process of (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

There total 6 articles about (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde (865262-74-4) + methyllithium (917-54-4) → (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol (915725-65-4) + (1S,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.tet.2006.08.058

Reference yield: 93.0%

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde (865262-74-4) + methyl magnesium iodide (917-64-6) → (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol (915725-65-4) + (1S,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/j.tet.2006.08.058

Reference yield:

(2S,4aS,7R,8aR)-3-benzyl-2-(2-bromophenyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazine (915725-70-1) + acetaldehyde (75-07-0,9002-91-9) → (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol (915725-65-4) + (1S,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)-ethanol

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; at -90 ℃;

DOI:10.1016/j.tet.2006.08.058

upstream raw materials:

2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde

methyl magnesium iodide

methyllithium

(2S,4aS,7R,8aR)-3-benzyl-2-(2-bromophenyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazine

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