[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Base Information

Chemical Name:[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid
CAS No.:1241896-94-5
Molecular Formula:C₁₇H₁₆F₃N₇O₄
Molecular Weight:439.354
Hs Code.:

Synonyms:[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

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Chemical Property of [5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

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Technology Process of [5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

There total 6 articles about [5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-66-7
1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

: 105-36-2
ethyl bromoacetate

: 1241898-67-8
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-1H-tetrazol-1-yl]acetic acid

: 1241896-94-5
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: 1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine; ethyl bromoacetate; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90 ℃; for 1h; Sealed vial;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1535-73-5
m-trifluoromethoxyaniline

: 1241898-67-8
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-1H-tetrazol-1-yl]acetic acid

: 1241896-94-5
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethoxyethoxyethanol / 6 h / 160 °C

2.1: N-ethyl-N,N-diisopropylamine / 16 h / Reflux

3.1: sodium acetate; iodine / chlorobenzene / 9 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

5.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 75 °C

6.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 90 °C / Sealrd tube

6.2: 0.5 h / 20 °C

With sodium azide; iodine; sodium acetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane; ethoxyethoxyethanol; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 1241898-63-4
3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}-4,5-dihydroisoxazole-5-carboxamide

: 1241898-67-8
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-1H-tetrazol-1-yl]acetic acid

: 1241896-94-5
[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; iodine / chlorobenzene / 9 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 75 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 90 °C / Sealrd tube

4.2: 0.5 h / 20 °C

With sodium azide; iodine; sodium acetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;