3--1-ethoxycarbonyl-1-iodopropane

Base Information

• Chemical Name: 3--1-ethoxycarbonyl-1-iodopropane
• CAS No.: 97579-96-9
• Molecular Formula: C₁₉H₂₄INO₄
• Molecular Weight: 457.308
• Mol file: 97579-96-9.mol

Synonyms:3--1-ethoxycarbonyl-1-iodopropane

Chemical Property of 3--1-ethoxycarbonyl-1-iodopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3--1-ethoxycarbonyl-1-iodopropane

There total 5 articles about 3--1-ethoxycarbonyl-1-iodopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-Bromo-4-(cyclohex-2-enyl-phenoxycarbonyl-amino)-butyric acid ethyl ester (97579-92-5) → 3--1-ethoxycarbonyl-1-iodopropane (97579-96-9)

Guidance literature:

With potassium iodide; 18-crown-6 ether; In acetone;

DOI:10.1016/S0040-4020(01)86134-2

Reference yield:

3-(N-2-cyclohexen-1-yl-N-phenoxycarbonylamino)-1-ethoxycarbonylpropane (97579-88-9) → 3--1-ethoxycarbonyl-1-iodopropane (97579-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, Me₃SiCl, 2.) Br₂ / 1.) THF, -78 deg C, 40 min, 50 min, 2.) THF, pentane, 10 min

2: 71 percent / KI / 18-crown-6 / acetone

With chloro-trimethyl-silane; bromine; potassium iodide; lithium diisopropyl amide; 18-crown-6 ether; In acetone;

DOI:10.1016/S0040-4020(01)86134-2

Reference yield:

ethyl γ-aminobutyrate hydrochloride (6937-16-2) → 3--1-ethoxycarbonyl-1-iodopropane (97579-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) K₂CO₃, 2.) K₂CO₃ / 1.) CH₃CN, 2.) CH₃CN

2: 1.) LDA, Me₃SiCl, 2.) Br₂ / 1.) THF, -78 deg C, 40 min, 50 min, 2.) THF, pentane, 10 min

3: 71 percent / KI / 18-crown-6 / acetone

With chloro-trimethyl-silane; bromine; potassium carbonate; potassium iodide; lithium diisopropyl amide; 18-crown-6 ether; In acetone;

DOI:10.1016/S0040-4020(01)86134-2

upstream raw materials:

2-Bromo-4-(cyclohex-2-enyl-phenoxycarbonyl-amino)-butyric acid ethyl ester

ethyl γ-aminobutyrate hydrochloride

phenyl chloroformate

rac-3-bromocyclohexene

Downstream raw materials:

3,4,4a,7,8,8a-Hexahydro-2H-quinoline-1,4-dicarboxylic acid 4-ethyl ester 1-phenyl ester

(4R,4aS,8aS)-3,4,4a,7,8,8a-Hexahydro-2H-quinoline-1,4-dicarboxylic acid 4-ethyl ester 1-phenyl ester