3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

Base Information

Chemical Name:3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene
CAS No.:1378239-12-3
Molecular Formula:C₂₁H₂₄O₅
Molecular Weight:356.419
Hs Code.:

Synonyms:3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

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Chemical Property of 3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

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Technology Process of 3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

There total 6 articles about 3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1378238-99-3
3,4-dimethoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

: 1378239-11-2
9-(4'-Hydroxy-3',5'-dimethoxyphenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-4-ol

: 1378239-13-4
3-methoxy-4-hydroxy-9-(3',4'-dihydroxy-5'-methoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

: 1378239-12-3
3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

Guidance literature:: 3,4-dimethoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene; With trimethylammonium heptachlorodialuminate; at 80 ℃; for 1h; Microwave irradiation; Inert atmosphere; Sealed tube;

With water;

Reference yield:

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1378239-11-2
9-(4'-Hydroxy-3',5'-dimethoxyphenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-4-ol

: 1378239-13-4
3-methoxy-4-hydroxy-9-(3',4'-dihydroxy-5'-methoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

: 1378239-12-3
3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

3.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

4.2: -78 - 20 °C

4.3: 20 °C

5.1: acetic acid / 4 h / Reflux

6.1: trimethylammonium heptachlorodialuminate / 1 h / 80 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With n-butyllithium; methanesulfonic acid; phosphorus pentoxide; trimethylammonium heptachlorodialuminate; potassium tert-butylate; hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexanes; 1.1: Wittig Reaction;

Reference yield:

: 1378238-71-1
(Z)/(E)-5-(2',3'-dimethoxyphenyl)pent-4-enoic acid

: 1378239-11-2
9-(4'-Hydroxy-3',5'-dimethoxyphenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-4-ol

: 1378239-13-4
3-methoxy-4-hydroxy-9-(3',4'-dihydroxy-5'-methoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

: 1378239-12-3
3,4-dimethoxy-9-(3',5'-dimethoxy-4'-hydroxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

2.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

3.2: -78 - 20 °C

3.3: 20 °C

4.1: acetic acid / 4 h / Reflux

5.1: trimethylammonium heptachlorodialuminate / 1 h / 80 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With n-butyllithium; methanesulfonic acid; phosphorus pentoxide; trimethylammonium heptachlorodialuminate; hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexanes;