ethyl 3-chloro-5-fluoro-4-methylbenzoate

Base Information

• Chemical Name: ethyl 3-chloro-5-fluoro-4-methylbenzoate
• CAS No.: 1239964-20-5
• Molecular Formula: C₁₀H₁₀ClFO₂
• Molecular Weight: 216.64
• Mol file: 1239964-20-5.mol

Synonyms:ethyl 3-chloro-5-fluoro-4-methylbenzoate

Chemical Property of ethyl 3-chloro-5-fluoro-4-methylbenzoate

Chemical Property:

Purity/Quality:

Ethyl3-chloro-5-fluoro-4-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-chloro-5-fluoro-4-methylbenzoate

There total 3 articles about ethyl 3-chloro-5-fluoro-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1239964-19-2) → ethyl 3-chloro-5-fluoro-4-methylbenzoate (1239964-20-5)

Guidance literature:

With copper dichloride; In methanol; water; at 90 ℃;

Reference yield:

3-fluoro-4-methyl-benzoic acid (350-28-7) → ethyl 3-chloro-5-fluoro-4-methylbenzoate (1239964-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 60 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Inert atmosphere

3: copper dichloride / water; methanol / 90 °C

With thionyl chloride; 4,4'-di-tert-butyl-2,2'-bipyridine; copper dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; water;

Reference yield:

ethyl 3-fluoro-4-methylbenzoate (86239-00-1) → ethyl 3-chloro-5-fluoro-4-methylbenzoate (1239964-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Inert atmosphere

2: copper dichloride / water; methanol / 90 °C

With 4,4'-di-tert-butyl-2,2'-bipyridine; copper dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; water;

upstream raw materials:

ethyl 3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

3-fluoro-4-methyl-benzoic acid

ethyl 3-fluoro-4-methylbenzoate

Downstream raw materials:

ethyl 4-(bromomethyl)-3-chloro-5-fluorobenzoate

3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzenesulfonic acid

tert-butyl 3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorophenylcarbamate

3-chloro-4-(2-(5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)ethyl)-5-fluorobenzoic acid