benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

Base Information

Chemical Name:benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate
CAS No.:852660-58-3
Molecular Formula:C₂₆H₃₃FN₂O₂
Molecular Weight:424.559
Hs Code.:

Synonyms:benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

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Chemical Property of benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

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Technology Process of benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

There total 8 articles about benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 852660-55-0
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

: 852660-58-3
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: formaldehyd; benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate; With sodium cyanoborohydride; acetic acid; In water; acetonitrile; at 20 ℃;

With sodium hydroxide; In water; acetonitrile;

Reference yield:

: 275815-60-6
(1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde

: 852660-58-3
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1,2-dichloro-ethane

1.2: 3.5 h / 20 °C

2.1: sodium cyanoborohydride / acetic acid / water; acetonitrile / 20 °C

With sodium cyanoborohydride; triethylamine; acetic acid; In water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 852660-53-8
6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime

: 852660-58-3
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 18 h / 3604.44 Torr

2.1: triethylamine / 1,2-dichloro-ethane

2.2: 3.5 h / 20 °C

3.1: sodium cyanoborohydride / acetic acid / water; acetonitrile / 20 °C

With hydrogenchloride; hydrogen; sodium cyanoborohydride; triethylamine; palladium 10% on activated carbon; acetic acid; In methanol; water; 1,2-dichloro-ethane; acetonitrile;