benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

Base Information

Chemical Name:benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate
CAS No.:852660-55-0
Molecular Formula:C₂₅H₃₁FN₂O₂
Molecular Weight:410.532
Hs Code.:

Synonyms:benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

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Chemical Property of benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

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Technology Process of benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

There total 5 articles about benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 275815-60-6
(1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde

: 852660-54-9
6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

: 852660-55-0
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: (1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde; 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; With triethylamine; In 1,2-dichloro-ethane;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3.5h;

Reference yield:

: 852660-53-8
6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime

: 852660-55-0
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 18 h / 3604.44 Torr

2.1: triethylamine / 1,2-dichloro-ethane

2.2: 3.5 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; water; 1,2-dichloro-ethane;

Reference yield:

: 29419-14-5
6-fluoro-2-tetralone

: 852660-55-0
benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.5 h / 20 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 18 h / 3604.44 Torr

3.1: triethylamine / 1,2-dichloro-ethane

3.2: 3.5 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; water; 1,2-dichloro-ethane;