3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine

Base Information

• Chemical Name: 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine
• CAS No.: 204850-72-6
• Molecular Formula: C₂₄H₂₄N₂O₄
• Molecular Weight: 404.466
• Mol file: 204850-72-6.mol

Synonyms:3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine

Chemical Property of 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine

There total 4 articles about 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N,N-Dimethylcarbamoyl chloride (79-44-7) + 2,2-diphenyl-propionic acid 3-hydroxy-pyridin-2-ylmethyl ester (403729-94-2) → 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine (204850-72-6)

Guidance literature:

With pyridine; at 55 ℃; for 0.5h;

DOI:10.1021/jm010196t

Reference yield: 51.0%

2,2-diphenylpropionyl chloride (40997-78-2) + 2-hydroxymethyl-3-dimethylaminocarbonyloxypyridine (403729-90-8) → 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine (204850-72-6)

Guidance literature:

In pyridine;

DOI:10.1016/j.bmcl.2005.07.034

Reference yield:

2,2-diphenylpropanoic acid (5558-66-7) → 3-[[(dimethylamino)carbonyl]oxy]2-(2',2'-diphenylpropionoxymethyl)pyridine (204850-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / thionyl chloride

2: 51 percent / pyridine

With thionyl chloride; In pyridine;

DOI:10.1016/j.bmcl.2005.07.034

upstream raw materials:

2,2-diphenylpropionyl chloride

2-hydroxymethyl-3-dimethylaminocarbonyloxypyridine

N,N-Dimethylcarbamoyl chloride

2,2-diphenyl-propionic acid 3-hydroxy-pyridin-2-ylmethyl ester