40997-78-2

Basic information

• Product Name: Benzeneacetyl chloride, a-methyl-a-phenyl-
• CAS NO: 40997-78-2
• Molecular Formula: C15H13ClO
• Molecular Weight: 244.721
• Mol File: 40997-78-2.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: Benzeneacetyl chloride, a-methyl-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetyl chloride, a-methyl-a-phenyl-(40997-78-2)
• EPA Substance Registry System: Benzeneacetyl chloride, a-methyl-a-phenyl-(40997-78-2)

Safety Data

• Hazardous Substances Data: 40997-78-2(Hazardous Substances Data)

Upstream product

• 5558-66-7 2,2-diphenylpropanoic acid 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 50354-48-8 methyl 2,2-diphenylpropionate 
• 5558-67-8 2,2-diphenylpropionitrile 
• 22875-82-7 2,2-diphenylpropanal 
• 86-29-3 Diphenylacetonitrile 
• 117-34-0 2,2-diphenylacetic acid 

Downstream Products

• 3579-27-9 γ-N,N-dimethylamiopropyl 2,2-diphenylpropionate 
• 74421-26-4 2,2-diphenylpropan-1-ol 
• 612-00-0 1,1'-ethylidenebis-benzene 
• 19303-32-3 1-methyl-1,3,3-triphenylindane 
• 120220-09-9 2,2-Diphenyl-propionic acid 1-methyl-piperidin-4-yl ester 
• 122020-52-4 N-Butyl-2,2-diphenyl-propionamide 
• 74-87-3 methylene chloride 
• 20912-56-5 1,1-diphenylethylamine 

Relevant articles and documents

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Decarbonylation of phenylacetic acids by high valent transition metal halides

Triphenylacetic acid underwent unusual decarbonylation when allowed to react with a series of halides of group 4-6 metals in their highest oxidation state, in dichloromethane at ambient temperature. Thus, the reaction of CPh3COOH with MoCl5, in 1:1 molar ratio, afforded the trityl salt [CPh3][MoOCl4], 1, in 79% yield, while the 1:2 reaction of CPh3COOH with NbF5 afforded [CPh3][NbF6], 2, in 70% yield, NbOF3 being the metal co-product. CPh3COOH reacted with NbCl5, TiF4 and WOCl4 to give mixtures of compounds, however the cation [CPh3]+ was NMR identified in each case. [CPh3][NbCl6], 3, was isolated from NbCl5 and CPh3COCl, prior to being generated from CPh3COOH and PCl5. The reaction of CPh3COOH with TiCl4 was non-selective, and the salt [CPh3][Ti2Cl8(μ-κ2-O2CCPh3)], 4, was obtained in 18% yield. The decarbonylation reactions of CMePh2COCl and CMe2PhCOCl by means of NbCl5 led to the indanes 5a-b, which were isolated in 79-97% yields after hydrolysis of the mixtures and subsequent alumina filtration of the organic phases. The reactions of CH(Ph)2COOH with NbCl5 and WCl6 afforded NbCl4(OOCCHPh2), 6, and CHPh2COCl, respectively, as the prevalent species. CPh2(CH2CH2Br)COOH did not undergo CO release when allowed to interact with WCl6, instead selective intramolecular condensation to C(Ph)2C(O)OCH2CH2, 7, occurred. MeCCCOOH underwent hydrochlorination by WCl6 to give MeC(Cl)CHCOOH, 8, in 72% yield. All the products were fully characterized by elemental analysis, IR and multinuclear NMR spectroscopy. In addition, the solid state structures of 1, 2, 4, 7, and 8 were elucidated by X-ray diffraction.

Palladium-catalyzed C(carbonyl)-C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols

A sulfur-containing auxiliary enabled palladium-catalyzed C(carbonyl)-C bond activation of amides was reported to form phenylcarbamate derivatives with alcohols. Both alkyl and benzyl alcohols could be employed well with yields up to 85%. Derivations from phenylcarbamates to ureas and thiocarbamates illustrated the potential applications of this sequential C-C cleavage/C-O coupling reaction.