methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Base Information

Chemical Name:methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610371-48-6
Molecular Formula:C₁₄H₁₅F₃N₂O₃
Molecular Weight:316.28
Hs Code.:

Synonyms:methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Property of methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Technology Process of methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 8 articles about methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 1610371-48-6
methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 2.08 h / 20 °C

2.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

3.1: silver carbonate / 1,4-dioxane / 50 °C / Inert atmosphere

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 4.08 h / 20 - 28.9 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

6.1: dimethyl sulfoxide / 40 °C / Cooling with ice

7.1: hydrogenchloride / dichloromethane; methanol / 20 °C

7.2: 20 - 40 °C

8.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

9.1: dihydrogen peroxide / ethyl acetate; water / 8 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; dihydrogen peroxide; potassium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; silver carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: ((4S,5R)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)methyl methanesulfonate

: 1610371-48-6
methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide / 40 °C / Cooling with ice

2.1: hydrogenchloride / dichloromethane; methanol / 20 °C

2.2: 20 - 40 °C

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

4.1: dihydrogen peroxide / ethyl acetate; water / 8 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; potassium acetate; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 118096-36-9
N'-(4-bromophenyl)-2,2,2-trifluoroacetohydrazide

: 1610371-48-6
methyl 2-((4S,5S)-1-(4-hydroxyphenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

2.1: silver carbonate / 1,4-dioxane / 50 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; water / 4.08 h / 20 - 28.9 °C

4.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.1: dimethyl sulfoxide / 40 °C / Cooling with ice

6.1: hydrogenchloride / dichloromethane; methanol / 20 °C

6.2: 20 - 40 °C

7.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

8.1: dihydrogen peroxide / ethyl acetate; water / 8 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; dihydrogen peroxide; potassium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; silver carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;