methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Base Information

Chemical Name:methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610371-74-8
Molecular Formula:C₁₄H₁₄BrF₃N₂O₂
Molecular Weight:379.177
Hs Code.:

Synonyms:methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Property of methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Technology Process of methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 7 articles about methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 1610371-24-8
2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610371-74-8
methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 - 40 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00982

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 1610371-74-8
methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 2.08 h / 20 °C

2.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

3.1: silver carbonate / 1,4-dioxane / 50 °C / Inert atmosphere

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 4.08 h / 20 - 28.9 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

6.1: dimethyl sulfoxide / 40 °C / Cooling with ice

7.1: hydrogenchloride / dichloromethane; methanol / 20 °C

7.2: 20 - 40 °C

With hydrogenchloride; sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; silver carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 118096-36-9
N'-(4-bromophenyl)-2,2,2-trifluoroacetohydrazide

: 1610371-74-8
methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

2.1: silver carbonate / 1,4-dioxane / 50 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; water / 4.08 h / 20 - 28.9 °C

4.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.1: dimethyl sulfoxide / 40 °C / Cooling with ice

6.1: hydrogenchloride / dichloromethane; methanol / 20 °C

6.2: 20 - 40 °C

With hydrogenchloride; sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; silver carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;