trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

Base Information

Chemical Name:trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid
CAS No.:1421930-35-9
Molecular Formula:C₂₆H₂₈F₂N₄O₃
Molecular Weight:482.53
Hs Code.:

Synonyms:trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

There total 9 articles about trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609978-88-2
methyl trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1421930-35-9
trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

Guidance literature:: methyl trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate; With water; sodium hydroxide; In methanol; at 65 ℃; for 1h;

With hydrogenchloride; In methanol; water; at 50 ℃; for 1.5h;

Reference yield:

: 32529-80-9,36218-60-7
trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane

: 1421930-35-9
trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 15 - 20 °C / Cooling with ice

2.1: isopropylmagnesium chloride / tetrahydrofuran; dichloromethane / 0.67 h / 0 - 5 °C

2.2: 2.25 h / 0 °C

2.3: 0 - 20 °C

3.1: ChiralPak AD-10 urn, 300x50 mm ID / ethanol / Resolution of racemate

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.2: 2.5 h / 90 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 1 h / 65 °C

5.2: 1.5 h / 50 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; isopropylmagnesium chloride; potassium acetate; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1411772-44-5
methyl trans-4-[1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1421930-35-9
trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ChiralPak AD-10 urn, 300x50 mm ID / ethanol / Resolution of racemate

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2.2: 2.5 h / 90 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 1 h / 65 °C

3.2: 1.5 h / 50 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; bis(pinacol)diborane; sodium hydroxide; In 1,4-dioxane; methanol; ethanol;