(1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

Base Information

• Chemical Name: (1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane
• CAS No.: 917484-74-3
• Molecular Formula: C₁₀H₁₄F₆N₂O₅S₂
• Molecular Weight: 420.354
• Mol file: 917484-74-3.mol

Synonyms:(1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

Chemical Property of (1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

There total 1 articles about (1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N,N’-(1R,2R)-cyclohexane-1,2-diylbis(1,1,1-trifluoromethanesulfonamide) (122833-60-7,153077-87-3) + acetyl chloride (75-36-5) → (1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane (917484-74-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -20 - 0 ℃; for 5h;

DOI:10.1021/ja310620c

Reference yield:

(1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane (917484-74-3) + (1S,2S)-N-acetyl(d3)-1,2-bis(trifluoromethanesulfonamido) cyclohexane + (1S,2R)-(+)-norphedrine (37577-28-9,58550-13-3,757124-50-8) → C11H12(2)H3NO2 (1415568-50-1) + N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]acetamide (126188-15-6)

Guidance literature:

In chloroform; at 23 ℃; for 1h;

DOI:10.1021/ja310620c

Reference yield:

(1R,2R)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane (917484-74-3) + (1S,2S)-N-acetyl(d3)-1,2-bis(trifluoromethanesulfonamido) cyclohexane + 2-aminocaprolactam (21568-87-6) → C9H14(2)H2N2O2 + N-acetyl-cyclolysine (118477-18-2)

Guidance literature:

In chloroform; at 23 ℃; for 1h;

DOI:10.1021/ja310620c

upstream raw materials:

N,N’-(1R,2R)-cyclohexane-1,2-diylbis(1,1,1-trifluoromethanesulfonamide)

acetyl chloride

Downstream raw materials:

N-acetyl-1-phenylethylamine

(S)-N-acetylphenylalanine

C₁₂H₁₂⁽²⁾H₃NO₃

C₉H₁₀⁽²⁾H₃N₃O₃