p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

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Chemical Name:p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate
CAS No.:133381-04-1
Molecular Formula:C₂₄H₂₄ClN₃O₁₂
Molecular Weight:581.92
Hs Code.:

Synonyms:p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

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Chemical Property of p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

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Technology Process of p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

There total 5 articles about p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 64370-35-0
p-nitrobenzyl glyoxylate

: 133380-99-1
(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one

: 133381-04-1
p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

Guidance literature:: In benzene; for 21h; Heating;

Reference yield:

: 73659-95-7,77003-49-7
(6RS,7SR)-7-acetyl-8-oxo-3-oxa-1-aza-bicyclo[4.2.0]octane-2-spirocyclohexane

: 133381-04-1
p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / chloramine-T / acetonitrile / 0.5 h / Ambient temperature

2: 91 percent / L-Selectride / tetrahydrofuran / 1 h / -70 °C

3: 1) lithium diisopropylamide / 1) THF, -70 deg C, 2) up to r.t.

4: 5 M sulphuric acid / 50 °C

5: 68 percent / benzene / 21 h / Heating

With sulfuric acid; chloroamine-T; L-Selectride; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile; benzene;

Reference yield:

: 106673-95-4,106758-30-9,133443-86-4,142924-03-6
(6RS,9RS)-7-chloro-7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane

: 133381-04-1
p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) lithium diisopropylamide / 1) THF, -70 deg C, 2) up to r.t.

2: 5 M sulphuric acid / 50 °C

3: 68 percent / benzene / 21 h / Heating

With sulfuric acid; lithium diisopropyl amide; In benzene;