Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Base Information

Chemical Name:Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester
CAS No.:254990-82-4
Molecular Formula:C₁₉H₂₃NO₅S
Molecular Weight:377.461
Hs Code.:

Synonyms:Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Suppliers and Price of Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

There total 7 articles about Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 254990-81-3
(R)-2-benzyl-3-[(N-benzyloxycarbonyl)amino]-1-propanol

: 254990-82-4
Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -30 ℃;
DOI:10.1016/S0957-4166(99)00371-7

Reference yield:

: 2612-30-8
2-benzyl-1,3-propanediol

: 254990-82-4
Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 3A molecular sieves; lipase Amono P supported on Celite / various solvent(s) / 5.7 h / 25 °C

2: Et₃N / CH₂Cl₂ / 2.5 h / -30 °C

3: 96 percent / sodium azide / dimethylformamide / 50 °C

4: 99 percent / pH 7 buffer; lipase Amano P / 22 h / 20 °C / pH 7

5: 94 percent / H₂O, PPh₃ / tetrahydrofuran / 6 h / 50 °C

6: 94 percent / 6N aq. NaOH / 0.17 h / 0 °C / pH 9

7: Et₃N / CH₂Cl₂ / -30 °C

With sodium hydroxide; sodium azide; 3 A molecular sieve; lipase Amano P; lipase Amono P supported on Celite; pH 7 buffer; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: mesylation / 3: Substitution / 4: Hydrolysis / 5: Staudinger reaction / 6: Acylation / 7: Substitution;
DOI:10.1016/S0957-4166(99)00371-7

Reference yield:

: 110270-49-0
(R)-3-acetoxy-2-benzyl-1-propanol

: 254990-82-4
Methanesulfonic acid (R)-2-(benzyloxycarbonylamino-methyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / -30 °C

2: 96 percent / sodium azide / dimethylformamide / 50 °C

3: 99 percent / pH 7 buffer; lipase Amano P / 22 h / 20 °C / pH 7

4: 94 percent / H₂O, PPh₃ / tetrahydrofuran / 6 h / 50 °C

5: 94 percent / 6N aq. NaOH / 0.17 h / 0 °C / pH 9

6: Et₃N / CH₂Cl₂ / -30 °C

With sodium hydroxide; sodium azide; lipase Amano P; pH 7 buffer; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: mesylation / 2: Substitution / 3: Hydrolysis / 4: Staudinger reaction / 5: Acylation / 6: Substitution;
DOI:10.1016/S0957-4166(99)00371-7