(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

Base Information

Chemical Name:(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one
CAS No.:1429386-06-0
Molecular Formula:C₂₁H₂₁Cl₂NO₃
Molecular Weight:406.309
Hs Code.:

Synonyms:(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

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Technology Process of (5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

There total 16 articles about (5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1429386-03-7
(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

: 1429386-06-0
(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

: 1429386-05-9
(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((R)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

: 1429386-06-0
(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1429386-06-0
(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 25 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 25 °C / Inert atmosphere

6.1: lithium triethylborohydride / tetrahydrofuran / Inert atmosphere

With hydrogenchloride; sodium hydride; lithium triethylborohydride; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm401767k