(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

Base Information

Chemical Name:(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate
CAS No.:1429386-03-7
Molecular Formula:C₂₃H₂₃Cl₂NO₄
Molecular Weight:448.346
Hs Code.:

Synonyms:(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

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Chemical Property of (S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

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Technology Process of (S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

There total 17 articles about (S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1429386-04-8
(R)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

: 1429386-03-7
(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

Guidance literature:: With sodium ethanolate; In ethanol; at 25 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield: 40.0%

: 1200828-74-5
ethyl α-bromocyclopropaneacetate

: 1429385-24-9
(5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

: 1429386-03-7
(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

: 1429386-04-8
(R)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

Guidance literature:: (5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl α-bromocyclopropaneacetate; In N,N-dimethyl-formamide; at 25 ℃; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1429386-03-7
(S)-ethyl 2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholino)-2-cyclopropylacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 25 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 25 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm401767k