Sceletium a4

Base Information

Chemical Name:Sceletium a4
CAS No.:35135-35-4
Molecular Formula:C20H24 N2 O2
Molecular Weight:324.42
Hs Code.:
Mol file:35135-35-4.mol

Synonyms:1H-Pyrrolo[2,3-f]quinoline,3a-(3,4-dimethoxyphenyl)-2,3,3a,4,5,9b-hexahydro-1-methyl-, (3aS-cis)-;Alkaloid A4, from Sceletium namaquense; Sceletium alkaloid A4

Suppliers and Price of Sceletium a4

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Sceletium a4

Chemical Property:

PSA：34.59000
LogP:3.29750

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Sceletium a4

There total 56 articles about Sceletium a4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: C₁₉H₁₉NO₄

: 74-89-5
methylamine

: 35135-35-4
3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

Guidance literature:: C₁₉H₁₉NO₄; methylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/anie.201807302

Reference yield: 67.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 207515-83-1
(3aS,9bR)-3a-(3,4-Dimethoxy-phenyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

: 35135-35-4
3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

Guidance literature:: With formic acid; In water;
DOI:10.1039/a709212a

Reference yield:

: 207515-62-6
(1S,4R,4aS,8aR)-7-(2-Benzyloxy-ethyl)-4,4a,8,8a-tetrahydro-1H-1,4-methano-naphthalen-5-one

: 35135-35-4
3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

Guidance literature:: Multi-step reaction with 22 steps

1: 1.) CuBr*SMe₂, Me₃SiCl, HMPA, 2.) acid / 1.) THF

2: diphenyl ether / 260 °C

3: DIBAL-H, CuI, HMPA / tetrahydrofuran

4: H₂ / 10percent Pd/C

5: imidazole / dimethylformamide

6: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

7: NaBH₄, CeCl₃*7H₂O

8: (CF₃CO₂)IPh

9: NaH / tetrahydrofuran

10: HClO₄, H₂O / tetrahydrofuran

11: 1,2-dichloro-benzene / 180 °C

12: 97 percent / I₂, pyridine / CH₂Cl₂

13: 91 percent / CuI, Et₃N / PdCl₂(PPh₃)2

14: 71 percent / TsOH / benzene

15: 100 percent / Bu₄NF / tetrahydrofuran

16: 90 percent / PPh₃, DIPAD / tetrahydrofuran

17: 86 percent / H₂ / Lindlar catalyst / methanol

18: N₂H₄*H₂O / ethanol / Heating

19: Et₃N / CH₂Cl₂

20: 42 percent / HCl, H₂O / tetrahydrofuran

21: TFA / CHCl₃

22: 67 percent / HCO₂H / H₂O

With pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; copper(l) iodide; chloro-trimethyl-silane; formic acid; perchloric acid; cerium(III) chloride; copper(I) bromide dimethylsulfide complex; (CF₃CO₂)IPh; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; iodine; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; hydrazine hydrate; diisopropyl (E)-azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; methanol; diphenylether; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; tert-butyl alcohol; benzene;
DOI:10.1039/a709212a