(1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene

Base Information

• Chemical Name: (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene
• CAS No.: 95019-24-2
• Molecular Formula: C₁₄H₁₇N
• Molecular Weight: 199.296
• Mol file: 95019-24-2.mol

Synonyms:(1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene

Chemical Property of (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene

There total 2 articles about (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-1-phenyl-ethylamine (2627-86-3) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → (1R,4R) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene (95119-33-8) + (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene (95019-24-2)

Guidance literature:

With acetic acid; In water; at 0 - 8 ℃; for 20h;

DOI:10.1080/00397919608003651

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-(-)-α-methylbenzylamine hydrochloride (17279-30-0) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → (1R,4R) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene (95119-33-8) + (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene (95019-24-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) H₂O, 0 deg C, 15 min, 2.) 0 deg C, 4 h;

DOI:10.1002/hlca.19930760307

Reference yield: 52.0%

dichloroacethyl chloride (79-36-7) + (1S,4S) 2-<(1'(S)-phenyl)-ethyl>-2-aza-bicyclo<2.2.1>hept-5-ene (95019-24-2) → (-)-(1R,6S,1'S)-5,5-dichloro-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>non-7-en-4-one

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 8h;

DOI:10.1002/hlca.19930760416

upstream raw materials:

formaldehyd

(S)-(-)-α-methylbenzylamine hydrochloride

cyclopenta-1,3-diene

(S)-1-phenyl-ethylamine