10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Base Information

• Chemical Name: 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one
• CAS No.: 118288-49-6
• Molecular Formula: C₁₉H₁₇ClN₂OS
• Molecular Weight: 356.876

Synonyms:10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Chemical Property of 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

There total 5 articles about 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-chlorophenylhydrazine hydrochloride (1073-70-7) + 7-Methyl-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-4-acetic acid (130058-64-9) → 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-49-6)

Guidance literature:

With sodium acetate; In ethanol; Heating;

DOI:10.1248/cpb.39.2556

Reference yield:

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one (18850-47-0) → 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-49-6)

Guidance literature:

Multi-step reaction with 5 steps

2: acetone / 3 h / Ambient temperature

3: methanol; H₂O / 1 h / Ambient temperature

4: conc. HCl, AcOH / 3 h / Heating

5: 40 percent / NaOAc / ethanol / Heating

With hydrogenchloride; sodium acetate; acetic acid; In methanol; ethanol; water; acetone;

DOI:10.1248/cpb.39.2556

Reference yield:

4-dimethylaminomethyl-7-methyl-3,4-dihydro-2H-benzo[b]thiepin-5-one (801213-99-0) → 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-49-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetone / 3 h / Ambient temperature

2: methanol; H₂O / 1 h / Ambient temperature

3: conc. HCl, AcOH / 3 h / Heating

4: 40 percent / NaOAc / ethanol / Heating

With hydrogenchloride; sodium acetate; acetic acid; In methanol; ethanol; water; acetone;

DOI:10.1248/cpb.39.2556

upstream raw materials:

4-chlorophenylhydrazine hydrochloride

7-Methyl-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-4-acetic acid

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one

4-dimethylaminomethyl-7-methyl-3,4-dihydro-2H-benzo[b]thiepin-5-one

Downstream raw materials:

10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 118288-49-6 10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send