N-Acetoacetbenzylamide

Base Information

• Chemical Name: N-Acetoacetbenzylamide
• CAS No.: 3283-23-6
• Molecular Formula: C11H11 N O3
• Molecular Weight: 205.20994
• Mol file: 3283-23-6.mol

Synonyms:Benzamide,N-acetoacetyl- (6CI,7CI,8CI); Acetoacetylbenzamide; N-Acetoacetylbenzamide

Chemical Property of N-Acetoacetbenzylamide

Chemical Property:

• PSA: 63.24000
• LogP: 1.31300

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetoacetbenzylamide

There total 4 articles about N-Acetoacetbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + benzamide (55-21-0,27208-38-4) → N-benzoylacetoacetamide (3283-23-6)

Guidance literature:

With Aliquat 336; In toluene; for 10h; Heating;

Reference yield: 82.0%

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + benzamide (55-21-0,27208-38-4) → N-benzoylacetoacetamide (3283-23-6)

Guidance literature:

at 120 - 130 ℃; for 0.5h;

Reference yield:

5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (85920-63-4) + benzamide (55-21-0,27208-38-4) → N-benzoylacetoacetamide (3283-23-6)

Guidance literature:

In chloroform; toluene; at 80 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.11.096

upstream raw materials:

4-methyleneoxetan-2-one

benzamide

2,2,6-trimethyl-4H-1,3-dioxin-4-one

5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

3-Acetyl-1-benzoyl-6-methyl-2,4(1H,3H)-pyridindion

6-methyl-2-phenyl-4H-1,3-oxazin-4-one

6-methyl-2-phenyl-3H-pyrimidin-4-one

Refernces

• 1、 Dehmlow, Eckehard V.,Shamout, Abdul Rahman. "Onium Salt-catalyzed Acylations with Diketene". . p. 2062 - 2067. Retrieved 2007/10/02.
• 2、 Sato, Masayuki,Kanuma, Norio,Kato, Tetsuzo. "Synthesis of N-Acylacetoacetamide using 2,2,6-Trimethyl-1,3-dioxin-4-one". . p. 1315 - 1321. Retrieved 2007/10/02.