4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Base Information

Chemical Name:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime
CAS No.:1586758-89-5
Molecular Formula:C₂₃H₁₇ClF₂N₂O₂
Molecular Weight:426.85
Hs Code.:

Synonyms:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Suppliers and Price of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

There total 8 articles about 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

: 622-95-7
4-chlorobenzyl bromide

: 1586758-89-5
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Guidance literature:: N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

4-chlorobenzyl bromide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-89-5
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

6.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

7.2: 2 h

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; iodine; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a

Reference yield:

: 1586758-77-1
N-(2-chloro-1-(4-formylphenyl)ethyl)-2,6-difluorobenzamide

: 1586758-89-5
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-(4-chlorobenzyl) oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 2 h

With hydroxylamine hydrochloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a