(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

Base Information

Chemical Name:(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate
CAS No.:1244033-28-0
Molecular Formula:C₂₂H₂₆O₄
Molecular Weight:354.446
Hs Code.:

Synonyms:(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

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Technology Process of (+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

There total 21 articles about (+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: (-)-(2R,6S)-6-[β-(p-hydroxyphenyl)ethyl]-2-(p-methoxyphenyl)tetrahydropyran

: 1244033-28-0
(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2021.132375

Reference yield: 7.0%

: (S)-4-(3-hydroxy-7-(4-methoxyphenyl)heptyl)phenyl acetate

: 1244033-28-0
(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at -10 ℃; for 0.166667h;
DOI:10.1002/hlca.201000096

Reference yield:

: (R)-7-(4-benzyloxyphenyl)-5-hydroxy-1-(4-methoxyphenyl)hept-2-yn-1-one

: 1244033-28-0
(+)-4-(2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethyl)phenyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / methanol / 12 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 10 h / 20 °C / 1551.49 Torr / Autoclave

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 6 h / 0 - 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 24 h / Inert atmosphere; Reflux

5: triethylamine; dmap / dichloromethane / 2 h / 20 °C

With dmap; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; palladium 10% on activated carbon; hydrogen; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.tet.2021.132375