3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

Base Information

Chemical Name:3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid
CAS No.:875654-44-7
Molecular Formula:C₃₈H₄₃NO₁₀
Molecular Weight:673.76
Hs Code.:

3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

Synonyms:3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

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Chemical Property of 3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

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Technology Process of 3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

There total 19 articles about 3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 875654-42-5
methyl 3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

: 875654-44-7
3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

Guidance literature:: methyl 3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate; With potassium hydroxide; In ethanol; water; for 3h; Heating;

With toluene-4-sulfonic acid; In dichloromethane; for 1h; Heating;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 875654-44-7
3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / potassium carbonate / dimethylsulfoxide / 2 h / 55 °C

2.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 81 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

3.1: 77 percent / sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 4 h / Heating

4.1: sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 18 h / Heating

4.2: 95 percent / hydrochloric acid / methanol / 1 h / Heating

5.1: KOH / H₂O; ethanol / 3 h / Heating

5.2: 91 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 1 h / Heating

With potassium hydroxide; tert.-butyl lithium; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; pentane; 3.1: Suzuki-Miyaura coupling / 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 875654-44-7
3,4-dihydro-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: m-chloroperbenzoic acid / CH₂Cl₂; H₂O / 3 h / 0 °C

1.2: 86 percent / potassium carbonate / methanol / 1 h / 20 °C

2.1: 68 percent / sodium hydride / tetrahydrofuran; hexane / 0 - 20 °C

3.1: 98 percent / N-bromosuccinimide / dimethylformamide / 0.5 h / 0 °C

4.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

4.2: 87 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

5.1: sodium carbonate / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 18 h / Heating

5.2: 95 percent / hydrochloric acid / methanol / 1 h / Heating

6.1: KOH / H₂O; ethanol / 3 h / Heating

6.2: 91 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 1 h / Heating

With potassium hydroxide; N-Bromosuccinimide; tert.-butyl lithium; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; pentane; 1.1: Baeyer-Villiger oxidation / 5.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2005.10.014