tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

Base Information

Chemical Name:tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate
CAS No.:1246246-94-5
Molecular Formula:C₁₇H₂₄FN₃O₅
Molecular Weight:369.393
Hs Code.:

Synonyms:tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

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Chemical Property of tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

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Technology Process of tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

There total 1 articles about tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 123183-72-2
N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane

: 1246246-94-5
tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

Guidance literature:: 2-fluoro-4-nitrobenzoic acid; With pivaloyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Cooling with ice;

N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 95.0%

: 1246246-94-5
tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

: 1246246-95-6
tert-butyl (3-{[(4-amino-2-fluorophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1246246-94-5
tert-Butyl (3-{[(2-fluoro-4-nitrophenyl)carbonyl](methyl)amino}propyl)methylcarbamate

: 1246246-96-7
1-{2-[{6-[(3-Fluoro-4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)amino]hexanoyl}(meth yl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2.2: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;