2-chloro-5-phenoxyaniline

Base Information

• Chemical Name: 2-chloro-5-phenoxyaniline
• CAS No.: 74865-98-8
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.671
• Mol file: 74865-98-8.mol

Synonyms:2-chloro-5-phenoxyaniline

Chemical Property of 2-chloro-5-phenoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5-phenoxyaniline

There total 6 articles about 2-chloro-5-phenoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

iodobenzene (591-50-4) + 3-amino-4-chlorophenol (16026-77-0) → 2-chloro-5-phenoxyaniline (74865-98-8)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 80 ℃; for 15h;

Reference yield:

diphenylether (101-84-8) → 2-chloro-5-phenoxyaniline (74865-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: glacial acetic acid; chlorine

2: glacial acetic acid; acetic acid anhydride; HNO₃ / <55

3: water; iron; iron (III)-chloride

With water; nitric acid; acetic anhydride; chlorine; iron(III) chloride; iron; acetic acid;

DOI:10.1021/ja01868a068

Reference yield:

4-chlorodiphenyl ether (7005-72-3) → 2-chloro-5-phenoxyaniline (74865-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; acetic acid anhydride; HNO₃ / <55

2: water; iron; iron (III)-chloride

With water; nitric acid; acetic anhydride; iron(III) chloride; iron; acetic acid;

DOI:10.1021/ja01868a068

upstream raw materials:

(4-chloro-3-nitro-phenyl)-phenyl ether

diphenylether

4-chlorodiphenyl ether

2-nitro-4-phenoxyphenylamine

Downstream raw materials:

1,2-dichloro-4-phenoxybenzene

(3-bromo-4-chloro-phenyl)-phenyl ether

(4-chloro-3-iodo-phenyl)-phenyl ether

3,4,4'-Trichlorobiphenyl ether

Refernces