Technology Process of 2-amino-3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazine
There total 3 articles about 2-amino-3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
2-(5-amino-6-benzyl-3-vinylpyrazin-2-yl)-5-methoxybenzaldehyde;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium fluoride / bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere
2.1: tetrabutyl-ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / Inert atmosphere; Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 1.5 h / 0 - 20 °C / Inert atmosphere
With
potassium fluoride; n-butyllithium; tetrabutyl-ammonium chloride;
bis-triphenylphosphine-palladium(II) chloride; bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
tetrahydrofuran; hexane; water; toluene;
1.1: Suzuki-Miyaura coupling / 2.1: Stille Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutyl-ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / Inert atmosphere; Reflux
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 1.5 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; tetrabutyl-ammonium chloride;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; hexane; toluene;
1.1: Stille Coupling;
