tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate

Base Information

• Chemical Name: tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate
• CAS No.: 869088-61-9
• Molecular Formula: C₂₃H₂₈ClNO₅
• Molecular Weight: 433.932
• Mol file: 869088-61-9.mol

Synonyms:tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate

Chemical Property of tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate

There total 2 articles about tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-33-8) + (+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-32-7) + 4-Chloroguaiacol (16766-30-6) → tert-butyl (2S)-2-[(R)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate + tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate (869088-61-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 18h;

Reference yield:

C17H25NO6S + 4-Chloroguaiacol (16766-30-6) → tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate (869088-61-9)

Guidance literature:

With caesium carbonate;

DOI:10.1016/j.bmcl.2008.03.050

Reference yield:

tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate (869088-61-9) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → (2S)-2-[(1S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine fumarate (869208-85-5)

Guidance literature:

tert-butyl (2S)-2-[(S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine-4-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

With sodium hydroxide; In water; pH=13;

(2E)-but-2-enedioic acid; In acetone; at 20 ℃;

upstream raw materials:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

4-Chloroguaiacol

Downstream raw materials:

(2S)-2-[(1S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine

(2S)-2-[(1S)-(4-chloro-2-methoxyphenoxy)(phenyl)methyl]morpholine fumarate