3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

Base Information

Chemical Name:3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine
CAS No.:1609654-80-9
Molecular Formula:C₁₉H₂₃F₃N₂O₃
Molecular Weight:384.398
Hs Code.:

Synonyms:3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

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Chemical Property of 3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

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Technology Process of 3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

There total 4 articles about 3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1609573-35-4
(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)boronic acid

: 258506-68-2
3-chloro-6-(trifluormethyl)pyridazine

: 1609654-80-9
3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

Guidance literature:: (5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)boronic acid; 3-chloro-6-(trifluormethyl)pyridazine; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.333333h; Inert atmosphere;

With 4-((tert-butylamino)methyl)-6-(4-chlorophenyl)-6'-(trifluoromethyl)-[2,3'-bipyridin]-3-ol hydrochloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 22h; Inert atmosphere; Sealed tube;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609654-80-9
3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere

4.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

4.2: 22 h / 80 °C / Inert atmosphere; Sealed tube

With n-butyllithium; bromine; potassium carbonate; triethylamine; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; hexane; dichloromethane; chloroform; water;

Reference yield:

: 2198-66-5
2-bromo-4-tert-butylphenol

: 1609654-80-9
3-(5-(tert-butyl)-2-((2-methoxyethoxy)methoxy)phenyl)-6-(trifluoromethyl)pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

3.2: 22 h / 80 °C / Inert atmosphere; Sealed tube

With n-butyllithium; potassium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water;