258506-68-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-trifluoromethyl-pyridazine is used as a reagent for the repositioning of antitubercular oxazoles, which are essential in the development of treatments for certain neglected tropical diseases. Its role in this process is crucial, as it aids in the modification and enhancement of existing antitubercular drugs to improve their efficacy and applicability in combating these diseases.

InChI:InChI=1/C5H2ClF3N2/c6-4-2-1-3(10-11-4)5(7,8)9/h1-2H

Upstream product

• 1514-87-0 metyhyl chlorodifluoroacetate 
• 135034-10-5 3-chloro-6-iodopyridazine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 628332-15-0 6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one 
• 174607-36-4 6-(trifluoromethyl)pyridazin-3-ol 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 174607-36-4 6-(trifluoromethyl)pyridazin-3(2H)-one 

Downstream Products

• 935777-24-5 3-amino-6-(trifluoromethyl)pyridazine 
• 174607-36-4 6-(trifluoromethyl)pyridazin-3-ol 
• 1084742-40-4 1-(4-fluorophenyl)-4-methyl-7-(6-(trifluoromethyl)pyridazin-3-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine 
• 1201014-16-5 4-[5-(6-trifluoromethyl-pyridazin-3-yl)-2,3-dihydro-indole-1-sulfonyl]-benzonitrile 
• 1255924-12-9 4-(3,4-dichlorophenyl)-7-(6-(trifluoromethyl)pyridazin-3-yl)-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 1255924-60-7 4-(4-chlorophenyl)-1,1-dimethyl-7-(6-(trifluoromethyl)pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline 
• 1621367-01-8 N-(3,4-difluorophenyl)-3-methyl-5-{[6-(trifluoromethyl)pyridazin-3-yl]amino}-1,2-thiazole-4-carboxamide 
• 1260494-22-1 tert-butyl 8-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-6-tosyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate 
• 1260493-86-4 tert-butyl 8-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-6-tosyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME

A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof has superior TRPA1 antagonist activity, and the compound or a pharmaceutically acceptable salt thereof is useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR SUBSTITUTED FIVE-MEMBERED RING HETEROCYLES

Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Polycyclic derivatives of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE

An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like. Provided are a condensed heterocyclic compound represented by the general formula (I): {wherein A1, A2 and A3 may be the same or different, and each represent a nitrogen atom or a CH group, R1 represents an alkyl group or the like, R2 represents a haloalkyl group or the like, R3 represents a hydrogen atom or the like, R4 represents a haloalkyl group or the like, R5 represents an alkyl group or the like, and m represents 0 or 2} or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.

PEST CONTROL AGENT COMPOSITION CONTAINING IMIDAZOPYRIDAZINE DERIVATIVE AND APPLICATION METHOD THEREFOR

PROBLEM TO BE SOLVED: To provide a novel technology for efficiently controlling pests difficult to control or impossible to control with conventional technologies. SOLUTION: There is provided a pest control agent composition by combining an imidazopyridazine derivative represented by the general formula (I) (where A1, A2 and A3 represent a CH group or a N group, R1 represents an alkyl group or the like, R2 represents a haloalkyl group, R3 represents a hydrogen atom or the like, R4 represents a haloalkyl group or the like, R5 represents an alkyl group or the like, and m is 0 or 2) or salts thereof and one or more compound selected from a group (B). The (B) group is pyrifluquinazon, tiadinil or the like. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts

Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate.

Concise synthesis of ω-fluoroalkylated ketoesters. A building block for the synthesis of six-, seven-, and eight-membered fluoroalkyl substituted 1,2-diaza-3-one heterocycles

A concise and general synthetic route toward the small and medium-sized fluoroalkyl substituted 1,2-diaza-3-one heterocyclic ring skeletons via a sequential reaction of condensation and ring-closure reaction of ω-fluoroalkylated ketoesters 4 with hydrazin