ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate
CAS No.:422560-55-2
Molecular Formula:C₁₆H₁₃ClFN₃O₂S
Molecular Weight:365.816
Hs Code.:

Synonyms:ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

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Chemical Property of ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

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Technology Process of ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

There total 6 articles about ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 101667-98-5
5-Methyl-4-chloro-6-ethoxycarbonylthieno<2,3-d>pyrimidine

: 422560-55-2
ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

Guidance literature:: With triethylamine; In ethanol; Reflux;
DOI:10.1080/14756366.2021.1933465

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 588715-47-3
C₁₂H₁₄N₂O₃S

: 422560-55-2
ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

Guidance literature:: With acetic acid; for 4h; Reflux;
DOI:10.1016/j.ejmech.2012.10.007

Reference yield:

: 4815-30-9
diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate

: 422560-55-2
ethyl 4–(3-chloro-4-fluorophenylamino)-5-methylthieno[2,3-d] pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / Cooling with ice; Microwave irradiation

2: isopropyl alcohol / 0.83 h / Microwave irradiation

With trichlorophosphate; In isopropyl alcohol; 1: |Vilsmeier-Haack Formylation;
DOI:10.1080/00397911.2011.607934